Research &
Publications
Research Grants
1.
2020
CytoSorbents Europe GmbH; Role: Co-Investigator at University Hospitals Leuven, Leuven, Belgium; Project title: Perfusate adsorption during ex vivo lung perfusion on discarded human lungs
2.
2018
CytoSorbents Europe GmbH; Role: Co-Investigator at University Hospital Zurich, Zurich, Switzerland; Project title: The effect of cytokine removal during ex vivo lung perfusion on post-transplant graft function
3.
2016
Zurich Lung League, Switzerland, Role: Leading Researcher at University Hospital Zurich, Zurich, Switzerland; Project title: The effect of lung volume reduction surgery on outcome after lung transplantation in patients with emphysema
4.
2015
Hartmann Müller Foundation, Switzerland, Role: Leading Researcher at University Hospital Zurich, Zurich, Switzerland; Project title: The role of cytokine filtration during ex vivo lung perfusion
5.
2012
CSL BEHRING LLC, Role: Leading Researcher at University Health Network, Toronto, ON, Canada; Project title: Pre-clinical trial of C1-INH and Alpha-1 Antitrypsin in pig lung transplantation models
PUBLICATIONS:
Peer-Reviewed Original Research Articles:
1.
2022
Iskender I,  Pecoraro Y, Moreno Casado P, Kubisa B, Schiavon M, Faccioli E, Ehrsam J, Damarco F, Nosotti M, Inci I, Venuta F, Van Raemdonck D, Ceulemans LJ. Lung transplantation in patients with a history of anatomical native lung resection. Interact CardioVasc Surg 2022;35(5):ivac256.Â
2.
2021
Iskender I, Arni S, Maeyashiki T, Citak N, Sauer M, Rodriguez JM,
Frauenfelder T, Opitz I, Weder W, Inci I. Perfusate adsorption during ex vivo
lung perfusion improves early post-transplant lung function. J Thorac
Cardiovasc Surg 2021;161(2):e109-e121.
3.
2020
Inci I, Arni S, Iskender I, Citak N, Rodriguez JM, Weisskopf M, Opitz I, Weder W,
Frauenfelder T, Krafft MP, Spahn D. Functional, metabolic and morphologic results of
ex vivo donor lung advanced perfluorocarbon based oxygen carrier emulsion application
in large animal transplantation model. Cells. 2020;9(11):2501.
4.
2020
Nosotti M, D’Ovidio F, Leiva-Juarez M, Keshavjee S, Rackauskas M, Van
Raemdonck D, Ceulemans LJ, Krueger T, Koutsokera A, Schiavon M, Rea F,
Iskender I, Moreno P, Alvarez A, Luzzi L, Paladini P, Rosso L, Bertani A,
Venuta F, Pecoraro Y, Al-Kattan K, Kubisa A, Inci I. Rare indications for a lung
transplant. A European Society of Thoracic Surgeons Survey. Interact
Cardiovasc Thorac Surg. 2020;31(5):638-643.
5.
2018
Iskender I, Cypel M, Martinu T, Chen M, Sakamoto J, Kim H, Yu K, Lin H,
Guan Z, Hashimoto K, Waddell TK, Liu M, Keshavjee S. Effects of warm
versus cold ischemic donor lung preservation on the underlying mechanisms of
injuries during ischemia and reperfusion. Transplantation 2018;102:760-8.
6.
2018
Inci I*, Iskender I*, Ehrsam J, Caviezel C, Hillinger S, Opitz, I, Schneiter D, Weder W.
Previous lung volume reduction surgery does not negatively affect survival after lung
transplantation. Eur J Cardiothorac Surg 2018;53:596-602. *Equally contributed
7.
2018
Iskender I, Cosgun T, Arni S, Trinkwitz M, Fehlings S, Yamada Y, Cesarovic N, Yu K,
Frauenfelder T, Jungraithmayr W, Weder W, Inci I. Cytokine filtration modulates
pulmonary metabolism and edema formation during ex vivo lung perfusion. J Heart
Lung Transplant 2018;37:283-91.
8.
2017
Yamada Y*, Iskender I*, Arni S, Hillinger S, Cosgun T, Yu K, Jungraithmayr W,
Cesarovic N, Weder W, Inci I. Ex vivo treatment with inhaled N-acetylcysteine in
porcine lung transplantation. J Surg Res 2017;218:341-7. *Equally contributed
9.
2017
Cosgun T*, Iskender I*, Yamada Y, Arni S, Lipiski M, van Tilburg K, Weder W, Inci
I. Ex vivo administration of trimetazidine improves post-transplant lung function in pig
model. Eur J Cardiothorac Surg 2017;52:171-7. *Equally contributed
10.
2017
Nakajima D, Liu M, Ohsumi A, Kalaf R, Iskender I, Hsin M, Kanou T, Chen M, Baer
B, Coutinho R, Maahs L, Behrens P, Azad S, Martinu T, Waddell TK, Lewis JF, Post
M, Veldhuizen RA, Cypel M, Keshavjee S. Lung Lavage and Surfactant Replacement
During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced
Donor Lung Injury. J Heart Lung Transplant 2017;36:577-85.
11.
2016
Mordant P, Nakajima D, Kalaf R, Iskender I, Maahs L, Behrens P, Coutinho, R, Iyer
RK, Davies JE, Cypel M, Liu, M, Waddell TK, Keshavjee S. Mesenchymal stem cell
treatment is associated with decresed perfusate concentration of IL-8 during ex vivo
perfusion of donor lungs after 18h preservation. J Heart Lung Transplant
2016;35:1245-54.
12.
2016
Iskender I, Sakamoto J, Nakajima D, Lin H, Chen M, Kim H, Guan Z, Del Sorbo L,
Hwang D, Waddell TK, Cypel M, Keshavjee S, Liu M. Human a-1 antitrypsin improves
early post-transplant lung function: Pre-clinical studies in a pig lung transplant model. J
Heart Lung Transplant 2016;35(7):913-21 Â
13.
2016
Linacre V, Cypel M, Machuca T, Nakajima D, Hashimoto K, Zamel R, Chen M,
Iskender I, dos Santos P, Waddell TK, Liu M, Keshavjee S. Importance of left atrial
pressure during ex vivo lung perfusion. J Heart Lung Transplant 2016;35(6):808-14.
14.
2016
Nakajima D, Cypel M, Bonato R, Machuca TN, Iskender I, Hashimoto K, Linacre V,
Chen M, Coutinho R, Azad S, Martinu T, Waddell TK, Hwang DM, Husain S, Liu M,
Keshavjee S. Ex vivo perfusion treatment of infection in human donor lungs. Am J
Transplant 2016;16(4):1229-37.Â
15.
2016
Hashimoto K, Kim H, Oishi H, Chen M, Iskender I, Sakamoto J, Ohsumi A, Guan Z,
Hwang D, Waddell TK, Cypel M, Liu M, Keshavjee S. Annexin V homodimer protects
against ischemia reperfusion-induced acute lung injury in lung transplantation. J
Thorac Cardiovasc Surg 2016;151(3):861-9.
16.
2016
Hsin MK, Iskender I, Nakajima D, Chen M, Kim H, dos Santos P, Sakamoto J, Lee J,
Hashimoto K, Harmantas C, Hwang D, Waddell TK, Liu M, Keshavjee S, Cypel M.
Extension of donor lung preservation with hypothermic storage after normothermic ex
vivo lung perfusion. J Heart Lung Transplant 2016;35(1):130-6.
17.
2014
dos Santos PR, Iskender I, Machuca T, Hwang D, de Perrot M, Liu M, Keshavjee S,
Waddell TK, Cypel M. Modified in vivo lung perfusion technique allows for prolonged
perfusion without acute lung injury. J Thorac Cardiovasc Surg 2014;147(2):774-82.
18.
2013
Sagiroglu G, Baysal A, Kiraz OG, Meydan B, Taşçı AE, Iskender I. Comparison of
continuous use of thoracic epidural analgesia and intercostal block for pain management
after thoracotomy. Kardiochirurgia i Torakochirurgia Polska 2013;10(3):244–250.
19.
2012
Kosar A, Kapicibasi HO, Alpay AL, Misirlioglu AK, Sonmez H, Iskender I, Demirhan
R. The experimental use of N-butyl cyanoacrylate tissue adhesive in pulmonary wedge
resections. Heart Lung Circ 2012;21(11):711-714.
20.
2012
Iskender I, Kapicibasi HO, Kadioglu SZ, Sevilgen G, Tezel C, Kosar A, Atasalihi A,
Kir A. Comparison of integrated positron emission tomography/computed tomography
and mediastinoscopy in mediastinal staging of non-small cell lung cancer: Analysis of
212 patients. Acta Chir Belg 2012;112(3):219-225.
21.
2012
Iskender I, Kadioglu SZ, Coskun T, Kapicibasi HO, Sagiroglu G, Kosar A, Kir A.
False positivity of mediastinal lymph nodes has negative effect on survival in potentially
resectable non-small cell lung cancer. Eur J Cardiothorac Surg 2012;41(4):874-879.
22.
2011
Iskender I, Kadioglu SZ, Coskun T, Kapicibasi HO, Sagiroglu G, Kosar A, Kir A.
False positivity of mediastinal lymph nodes has negative effect on survival in potentially
resectable non-small cell lung cancer. Eur J Cardiothorac Surg 2012;41(4):874-879.
23.
2011
Iskender I, Tezel C, Kadioglu SZ, Kir A. The role of standard and extended cervical
mediastinoscopy in staging of non-small cell lung cancer patients. Turk Gogus Kalp
Dama 2011;19(3):405-409.
24.
2011
Iskender I, Kadioglu SZ, Kosar A, Atasalihi A, Kir A. Is there any maximum
standardized uptake value variation among positron emission tomography scanners for
mediastinal staging in non-small cell lung cancer? Interact CardioVasc Thorac Surg
2011;12(6):965-969.
25.
2008
Iskender I, Misirlioglu AK, Alpay L, Kir A, Atasalihi A. Acute cardiac herniation after
right pericardiopneumonectomy. Turk Gogus Kalp Dama 2008;16(4):263-264.
Turkish.
26.
2008
Kapicibasi HO, Iskender I, Sonmez H, Kir A, Atasalihi A. Mediastinum based giant
lipoma. Turk Thorac J 2008;9(3):131-132.
Book Chapters
1.
2010
Kir A, Iskender I. Surgery for tuberculosis. In: Ozkara S, Kilicaslan Z, editors.
Tuberculosis. Istanbul: Turkish Thoracic Society Books 2010;11:554-564. Turkish
2.
2021
Kapicibasi HO, Iskender I. Tube thoracostomy complications. In: Kutlu CA, Olgac G,
editors. Chest tube management in thoracic surgery. Ankara: Turkiye Klinikleri Thoracic Surgery Special Topics. 2022;1:20-20. Turkish